This paper presents a gesture recognition system based on the pressure changes produced by wrist tendon movements for wearable devices. The data of the pressure variations are captured by means of flexible and ultrathin force resistive sensors. A learning algorithm, Support Vector Machine, helps the system to distinguish various hand gestures through developed programming on MATLAB after extracting the key features of data. In order to achieve rapid gesture recognition with a shorter computational time, higher precision and less space complexity, genetic optimization algorithm is used to find the optimal parameter c (cost factor) and g (kernel function parameters) in SVM algorithm. The SVM parameter optimization improves the classification accuracy and the performance of the classifier. Finally, developed wearable resistive-based wrist-worn gesture sensing system classifies the hand gesture with high accuracy (>70%) and the results are displayed on the GUIDE user interface. © 2019 IEEE.