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The hypolipidemic activity of novel benzofuran-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats: A comparison with bezafibrate
Shattat G., Al-Qirim T., Sweidan K., , El-Huneidi W., Al-Hiari Y.
Published in
2010
PMID: 20590406
Volume: 25
   
Issue: 6
Pages: 751 - 755
Abstract
Using Triton WR-1339-induced hyperlipidemic rats as an experimental model, we investigated whether compound 4 [N-(9,10-dihydro-9,10-dioxoanthracen-2-yl) bezofuran-2-carboxamide] and compound 5 [N-(4-benzoylphenyl)benzofuran-2- carboxamide], two novel anti-hyperlipidemic agents, have any effect on plasma triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol levels (HDL-C) levels. The tested animals were divided into control (CG), hyperlipidemic (HG), and compounds 4, 5, and bezafibrate (BF) treated groups. At a dose of 15mg/kg body weight, compounds 4, 5, and BF significantly reduced elevated plasma TG levels after 7 and 24h. Furthermore, HDL-C levels were remarkably increased in all treated groups after 7 and 24h compared to the hyperlipidemic control group. However, only compounds 4 and 5 treated groups clearly showed a significant reduction in plasma total cholesterol levels after 7 and 24h. It is therefore reasonable to assume that compounds 4 and 5 may have promising potential in the treatment of hyperlipidemia and atherosclerosis. © 2010 Informa UK, Ltd.
About the journal
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
ISSN14756366
Open AccessNo