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The GC-MS detection and characterization of reticuline as a marker of opium use
A.M. Al-Amri, R.M. Smith, , M.H. Juma'a
Published in Elsevier Ireland Ltd
PMID: 15036439
Volume: 140
Issue: 2-3
Pages: 175 - 183
Reticuline (a precursor of opium alkaloids) was detected and characterised as its trimethylsilyl ethers, acetyl esters and methyl ethers by GC-EIMS and GC-CIMS in opium and the urine of opium users after hydrolysis by acid or β-glucuronidase as coextractive of morphine. Because this compound cannot be detected in heroin and poppy seeds, it is suggested as a differentiating marker between opium and heroin use, opium and poppy seeds use, or opium and "pharmaceutical" codeine use in cases when opiate use has been confirmed by detection of morphine and codeine in the urine. As well as being a constituent of opium, reticuline in the urine of opium users may also result from the metabolic demethylation of the three other benzyltetrahydroisoquinoline opium alkaloids: codamine, laudanosine and laudanine. © 2003 Elsevier Ireland Ltd. All rights reserved.
About the journal
JournalData powered by TypesetForensic Science International
PublisherData powered by TypesetElsevier Ireland Ltd