Objective: The primary objective of this study was to ascertain the association of anaerobic bacteria in intrapulmonary infections and their susceptibility pattern to commonly prescribed antibiotics. Methods: One hundred clinical samples (85 broncho-alveolar lavage and 15 lung abscess aspirates) from suspected intrapulmonary infection cases were investigated in order to determine the role of anaerobic bacteria in these infections. The anaerobic bacterial isolates were identified by using the Vitek Anaerobic Card System and conventional methods. Susceptibility of these isolates was determined by Etest method against eight commonly prescribed antibiotics. Results: A total of 42 anaerobes were isolated, of which Prevotella spp. were the commonest isolates, made up of 42.9% (18/42), followed by Peptostreptococcus spp. 33.3% (14/42). Only two Bacteroides fragilis strains were isolated. All the isolates were sensitive to metronidazole, clindamycin, imipenem and meropenem; however, one Prevotella was resistant to pipera-cillin-tazobactam. The two B. fragilis isolates were susceptible to metronidazole, imipenem, meropenem and piperacillin-tazobactam and one was found to be resistant to clindamycin. Conclusion: Overall, Prevotella spp. were found to be the predominant anaerobic bacteria associated with intrapulmonary infections in Kuwait. All the commonly prescribed antibiotics had excellent in vitro activities against nearly all the isolates.
|Journal||Medical Principles and Practice|