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Temperature dependence and thermodynamics of partitioning of clofazimine analogues in the n-octanol/water system
Quigley J.M., Fahelelbom K.M.S., Timoney R.F., Corrigan O.I.,
Published in
1990
Volume: 58
   
Issue: 2
Pages: 107 - 113
Abstract
The partition coefficient of eight N2-substituted phenazines was measured at four temperatures (range 20-55°C) in the n-octanol/water system. The apparent molal partition coefficients, Km', were calculated from the distribution results. Plots of log Km vs. T-1 were linear and the thermodynamic parameters for the solute transfer were evaluated from the Van't Hoff isochore. A relationship between log Km and log P was derived. © 1990.
About the journal
JournalInternational Journal of Pharmaceutics
ISSN03785173
Open AccessNo