Header menu link for other important links
Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF3-promoted reaction of hydrazine with 2-alkoxy pyridines
F.E. Goda, A.A.-M. Abdel-Aziz,
Published in Elsevier
PMID: 15051053
Volume: 12
Issue: 8
Pages: 1845 - 1852
Some new 2-alkoxy-3-cyano-4,6-diarylpyridines 3,4 were synthesized by condensation of different α,β-unsaturated ketones 1 with malononitrile 2, followed by cyclization in sodium alkoxide/alcohol system. Lewis acid-catalyzed reaction of 4 with hydrazine afforded the corresponding 1H-pyrazolo[3,4-b]pyridines 5. The potency of the results as antimicrobial agents has been evaluated. The structure of the newly prepared compounds was assessed by microanalysis, IR and NMR spectra. Molecular mechanics (MM2) and semiemperical (AM1) molecular orbital calculations have been performed for the most biologically active compounds 5b and c to get insight into their molecular structures and to learn more about their stable molecular conformations. © 2004 Elsevier Ltd. All rights reserved.
About the journal
JournalData powered by TypesetBioorganic and Medicinal Chemistry
PublisherData powered by TypesetElsevier
Open AccessNo
Concepts (6)
  •  related image
  •  related image
  •  related image
  •  related image
    Conformational analysis
  •  related image
    Molecular mechanics
  •  related image
    Semiemperical molecular orbital