Solubility is an important feature in assessing the clinical durability of luting cements. Solubility may cause degradation of the cement, leading to debonding of the restoration and recurrent decay. The aim of this study was to evaluate and compare water solubility values of luting resin cement with other three conventional luting cements Four commercial dental luting cement materials were selected: GIC cement (SPOFA DENTAL a.s, Markova 238), Zinc polycarboxylate cement (SS White Group.P.C.I, Unit 9 Madleaze Estate, Bristol Road, England), Zinc Phosphate cement (SPOFA DENTAL a.s Praha, Cernok.) and Resin cement (Densply Caulk 38 West Clarke Ave,U.S.A). Ten disc specimens were prepared for each cement material using a stainless steel mold with 10 mm in inner diameter and 2 mm in thickness. Water solubility of different cement materials were calculated by weighting the samples before and after water immersion (15 days) and desiccation. Data were analyzed by one-way ANOVA and Student t-test at 5% level of significance. Statistical analysis of data by using one-way analysis of variance (ANOVA) revealed that, there was statistically significant difference (P<0.05) in solubility values between the four luting cements being tested. Resin cement has the highest resistance to solubility in comparison with other conventional luting cements.