The main objectives of this project is to explore and record the trend or pattern of scientific research articles conducted on different novel drug delivery systems, over the last 32 years (1980-2012) and try to explain possible reasons that lead to such trend. Pub Med, has been used as a standard website to search for scientific articles, using different keywords related to the above mentioned topics. Published research articles on different novel drug delivery systems were recorded and analyzed to study their trends. Bar-charts showing the annual number of published articles, the total number of articles that has been published, as well as graphs showing the publications growth rates during (1980-2012), were constructed, to show the trend of such research. Analysis of the collected research articles, over the entire period of study, have indicated that research articles on novel drug delivery systems especially nanoparticles, liposomes, microspheres, and buckyballs have shown a clear escalating pattern in recent years.