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Polyploidization of rat hepatocytes due to cell fusion caused by radiations of different LET

, Giliano N. Ya, Malinovsky O. V, Baldychev A. S, Smolin V. A
Published in National Library of Medicine
Volume: 28
Issue: 1
Pages: 68 - 73

The method of flow cytometry was used to study polyploidization of hepatocytes following X-, gamma-, and neutron-irradiation. Ionizing radiation was shown to induce cell polyploidization by two different ways: (1) cells and nuclei fusion, and (2) restriction of mitosis after DNA replication. RBE of 14 MeV neutrons with respect to fusion was about 5.10(3). With neutron irradiation, the sensitivity of cells by fusion was not lower than that by chromosome mutations.

About the journal
PublisherNational Library of Medicine
Open AccessNo