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Organogels in drug delivery: A special emphasis on organogels pluronic lecithin
Alsaab H., Bonam S.P., Bahl D., Chowdhury P., Alexander K.,
Published in Canadian Society for Pharmaceutical Sciences
PMID: 27518174
Volume: 19
Issue: 2
Pages: 252 - 273
Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route. © 2016, Canadian Society for Pharmaceutical Sciences. All rights reserved.
About the journal
JournalJournal of Pharmacy and Pharmaceutical Sciences
PublisherCanadian Society for Pharmaceutical Sciences
Open AccessNo