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Neuroprotective antioxidant effect of portulaca quadrifida linn. Leaves extract on immobilization stress-induced changes in rat’s brain
Published in Innovare Academic Sciences
2018
Volume: 11
   
Issue: 10
Pages: 378 - 381
Abstract
Objective: The current study was established to illustrate the effect of this plant’s active constituents on stress-induced diseases that include oxidation damage to cellular components, especially the brain. Methods: Immobilization stress method is induced and initiated by putting separated animals in specially prepared mesh cages on a wooden plank. The animals were exposed to 6 h of stress. Wistar male rats were selected weighing (180–200 g). A total of 54 rats were selected and separated into nine groups and only six experimental rats were kept in each group. Results: The post-stress oral treatment of extract (100 mg/kg body weight) was more efficient in restricting stress-induced decline of superoxide dismutase (p<0.05), glutathione (GSH)-S-transferase (p<0.02), catalase (p<0.05), and GSH (p<0.05) and an enhanced level of thiobarbituric acid reactive substance (p<0.01) compared to stress alone or pre-stress extract treatments. Conclusion: The extract showed a significant resistance toward the oxidative metabolism triggered by restraint stress, though the post-extract treatment (curative) was observed to be more effective in restoring the altered oxidative metabolism compared with pre-extract treatment (prophylactic). © 2018, Innovare Academics Sciences Pvt. Ltd. All rights reserved.
About the journal
JournalAsian Journal of Pharmaceutical and Clinical Research
PublisherInnovare Academic Sciences
ISSN9742441
Open AccessNo
Concepts (5)
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    Antioxidant
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    Immobilization
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    Neurodegenerative diseases
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    Portulaca quadrifida
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    Stress