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Mortality of leptospirosis associated acute kidney injury (LAKI) & predictors for its development in adults: A systematic review
Published in Elsevier
2019
PMID: 31281106
Volume: 12
   
Issue: 6
Pages: 751 - 759
Abstract
Leptospirosis is the most widely spread zoonosis and Leptospirosis Associated Acute Kidney Injury (LAKI) is common and fatal if not properly and swiftly treated. The aim of this review is to evaluate the mortality of LAKI and to identify the risk factors for its development. An electronic search was performed to identify the studies included LAKI patients series. Only studies which investigated mortality or risk factors for LAKI development in adults were included. Twenty-three studies with 24 patients series were included in the final analysis and included 1698 patients. The median series mortality was 10.05% (range 0–33.3%) with a total of 223 death. Only four studies identified the independent risk factors for LAKI development which were oliguria, jaundice, arrhythmia, crackles, elevated direct bilirubin level, elevated activated prothrombin time, hyperbilirubinemia and leukocytosis. Although the mortality of LAKI is high, its predictors are not studied enough in literature. © 2019 The Authors
About the journal
JournalData powered by TypesetJournal of Infection and Public Health
PublisherData powered by TypesetElsevier
ISSN18760341
Open AccessYes
Concepts (6)
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    Leptospirosis associated acute kidney injury
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    Predictors
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    Mortality
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    Clinical characters
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    Adults
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    Systematic review