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Immunization with outer-membrane protein(s) of Bacteroides fragilis: an experimental study in mice
Khanna T., , K. Ganguly N., Majumdar S.
Published in National Library of Medicine
Volume: 10
Issue: 6
Pages: 645 - 647

A crude outer-membrane protein (OMP) preparation from a strain of Bacteroides fragilis, grown in supplemented brain-heart infusion broth, was tested for its protective effect against subcutaneous infection in mice. Immunization with six doses, each of 100, 150 or 200 μg OMP preparation, gave some protection: abscesses completely disappeared 15 to 22 days after immunization. In non-immunized animals and animals immunized with doses of 10, 20, 40 or 80 μg each, well demarcated abscesses were seen beyond day 22 post-immunization. Although crude OMP elicited good antibody response, with maximum titres on day 4 post-immunization, high titres could not be associated with healing of the abscesses.

About the journal
JournalWorld Journal of Microbiology and Biotechnology
PublisherNational Library of Medicine
Open AccessNo