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Ghrelin Structure and It’s Receptors: A Review

Published in Quest Journals
Volume: 3
   
Issue: 5
Pages: 8 - 13
Abstract

Ghrelin is a peptide hormone that consists of 28 amino acids. In December 1999, ghrelin was first reported as an endogenous ligand for the former orphan receptor growth hormone secretagogue receptor (GHS-R) 1a. Ghrelin was found to be able to activate this receptor and to stimulate growth hormone release from the pituitary in a dose dependent manner. Ghrelin has been found to be produced primarily in the stomach and then secreted into the blood stream. Within the stomach, ghrelin is produced by enteroendocrine cells in the oxyntic mucosa. Subsequently, it has been found that ghrelin exerts pleiotropic activity. It influences not only GH release but also food intake, function of gastrointestinal tract and cardiovascular system, sleep patterns as well as cancer proliferation.

About the journal
JournalJournal of Research in Pharmaceutical Science
PublisherQuest Journals
Open AccessYes