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Extemporaneous furosemide suspensions for pediatrics use prepared from commercially available tablets
H.S. Ali, R. Saad, A. Ahmed,
Published in Publishers
2016
Volume: 7
   
Issue: 2
Pages: 75 - 83
Abstract
Objective: Three furosemide aqueous suspensions for paediatric oral usage (2 mg/ml) were investigated to determinate its physicochemical stability under different storage conditions. Method: Formulations using sugar syrup and sugar free vehicles were stored at 4 and 25°C and the furosemide content was determined by spectrophotometer. Each sample was analyzed by triplicate at different time points (0, 7, 14, 28, 56, 72 and 90 days). Results: Liquid suspensions were successfully formulated from commercially available tablets. In both cases, samples showed suitable physical stability. Furosemide was chemically stable in aqueous suspension during the 90 days of the study at the two storage temperatures. Conclusions: All the tried oral liquid formulations can be conserved at 4 and 25°C at least 56, 72 and 90-day period.
About the journal
JournalInternational Journal of Current Pharmaceutical Review and Research
PublisherPublishers
ISSN0976822X
Open AccessNo
Concepts (5)
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    Furosemide
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    Hypertension
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    Loop diuretics drugs
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    Paediatric oral suspension
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    Stability