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Effect of some essential amino acids on serum lipids in the rabbit
Published in
Volume: 7
Issue: 7
Pages: 771 - 778
Stomach-feeding of some L-essential amino acids that include Leucine (Leu), Isoleucine (Ile), Lysine (Lys), Methionine (Met), Phenylalanine (Phe) and Tryptophan (Try) to young rabbits for 20 consecutive days caused a significant increase in serum lipids. As few as two amino acids mixture (Ile, Met) and (Leu, Phe) caused significant increase in cholesterol, triglyceride, total lipids and β-lipoprotein, serum levels in the rabbit. Most significant effect was obtained when the mixture fed to rabbits contained all six amino acids. Cessation of treatment for 15 days caused regression of cholesterol and triglyceride levels to near normal values and clofibrate administered simultaneously with the mixture of six amino acids abolished the hyperlipidemic effects and produced a significant decrease in cholesterol and triglyceride levels. These results demonstrate that long-term forced feeding of pure L-essential amino acids caused a significant increase in serum lipids of young rabbits. © 1987 Pergamon Journal Ltd.
About the journal
JournalNutrition Research