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Effect of chromatographic conditions on liquid chromatographic chiral separation of terbutaline and salbutamol on Chirobiotic V column
H. Hashem, C. Tründelberg, , T. Jira
Published in Elsevier
PMID: 21855076
Volume: 1218
Issue: 38
Pages: 6727 - 6731
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the best separation. The salt concentration in the mobile phase and pH value were found to be the most important chromatographic factors affecting separation. Separation of enantiomers of these two basic analytes was complete in less than 10. min without applying ammonium trifluoroacetate (ATFA) or triethylamine (TEA) salts. © 2011 Elsevier B.V.
About the journal
JournalData powered by TypesetJournal of Chromatography A
PublisherData powered by TypesetElsevier
Open AccessNo
Concepts (5)
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    Chirobiotic v
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    Polar ionic mode