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Decorosides A and B, Cytotoxic Flavonoid Glycosides from the Leaves of Rhododendron decorum
Published in SAGE Publications
2014
Volume: 9
   
Issue: 4
Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-α-L-arabinopyranosyl(l→6)-β-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

About the journal
JournalData powered by TypesetNatural Product Communications
PublisherData powered by TypesetSAGE Publications
ISSN1934-578X
Open AccessYes