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Anaerobic bacterial flora of intra-abdominal infections and their antimicrobial susceptibility pattern in Kuwait
, O. Rotimi V., Dhar Rita, D. Chugh T., M. Dhar P., Ghali Adel, Saad Adel, C. Sanyal S., L. Varghese T.
Published in Elsevier
Volume: 7
Issue: 6
Pages: 291 - 295

Clinical samples obtained from 200 patients with intra-abdominal infections were investigated for the presence of anaerobic bacteria. The majority of samples were from patients with appendicitis (108, 54%) followed by peritoneal abscess/peritonitis (37, 18.5%). A total of 153 anaerobes were isolated from 83 culture positive specimens with an isolation rate of 1.8 per sample. Ninety (59%) yielded Bacteroides fragilis group and B. fragilis stricto sensu accounted for half of them. Other isolates were 36 (23.5%) Prevotella species and 15 (9.8%)Peptostreptococcus micros . The susceptibility of the 153 isolates against eight antibiotics was determined by the E-test. All the isolates were susceptible to metronidazole, MIC90s varying between 1–2 μg/mL. ThePrevotella spp., Peptostreptococcus spp., Fusobacterium spp. and Porphyromonas spp. were all susceptible to clindamycin (MIC90s=0.25–2 μg/mL respectively), imipenem (MIC90s=0.12–0.5μg/mL respectively) and meropenem (MIC90=0.25 μg/mL each). About 25% of the B. fragilis group were resistant to clindamycin with MIC more than 256 μg/mL. Piperacillin-tazobactam also exhibited excellent in vitro activity against all the isolates (MIC90=0.25 μg/mL).

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PublisherData powered by TypesetElsevier
Open AccessNo