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Advances in ultrasound mediated transdermal drug delivery
S. Daftardar, R. Neupane, , J. Renukuntla, A.K. Tiwari
Published in Bentham Science Publishers
PMID: 30747058
Volume: 25
Issue: 4
Pages: 413 - 423
Low frequency ultrasound-assisted drug delivery has been widely investigated as a non-invasive method to enhance the transdermal penetration of drugs. Using this technique, a brief application of ultrasound is used to permeabilize skin for a prolonged time. In this review, an overview on ultrasound is detailed to help explain the parameters that could be modulated to obtain the desired ultrasound parameters for enhanced transdermal drug delivery. The mechanisms of enhancement and the latest developments in the area of ultrasound-assisted transdermal drug delivery are discussed. Special emphasis is placed on the effects of ultrasound when used in combination with microneedles, electroporation and iontophoresis, and penetration enhancers. Further, this review summarizes the effect of ultrasound on skin integrity and the regulatory requirements for commercialization of the ultrasound based transdermal delivery instruments. © 2019 Bentham Science Publishers.
About the journal
JournalCurrent Pharmaceutical Design
PublisherBentham Science Publishers
Open AccessNo
Concepts (7)
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    Low frequency ultrasound-assisted drug delivery
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    Ultrasound bioeffects
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    Skin integrity
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