Zinc Nanoparticles: Advancement in Synthetic Method, Mechanisms, and Synergistic Anticancer Potential

Purpose: The review aimed to discuss several recent research studies focused on plant-mediated zinc oxide nanoparticles anticancer potential. To review the anticancer activity of plant-mediated zinc oxide nanoparticles, we therefore thoroughly evaluate the literature of original research in this field. Recent Findings: The green synthesis approach of ZnO NPs from plant extracts become the focus of research attention in the era of environment-friendly development due to simplicity, low cost, and environment sustainability compared to chemical and physical routes. The plant-mediated nanoparticles consist of wider applications in health care. Cancer has a complicated pathophysiology and is one of the main causes of mortality and morbidity. Due to the existing difficulties in treating cancer with conventional medicines, nanotechnology is emerging with greater advancements. Improved surface properties enable nanoparticles to diffuse more readily within tumor cells, minimizing toxicity and providing the right quantity of medication at the tumor location. Google Scholar, PubMed, Scopus, Web of Science, and Science Direct, databases were screened for online publications to collect relevant knowledge. Summary: According to recent research, nano-therapeutics offer the potential for both infectious and non-infectious disorders. When compared to traditional modalities, these novel approaches to nanodelivery and administration have shown to be significantly advantageous. In this review, we have provided comprehensive overview of zinc oxide nanoparticles potential to deliver anticancer medications to tumor cells. Taken together, this review has shown effective anticancer properties of ZnO NPs due to their biocompatibility and enhanced anticancer activity in case of combinatorial ZnO NPs.