Versatility of acetalated dextran in nanocarriers targeting respiratory diseases

Parteek Prasher; Mousmee Sharma; Sachin Kumar Singh; Monica Gulati; Deepak Kumar; Gaurav Gupta; Dinesh Kumar Chellappan; Brian Gregory George Oliver; Peter R. Wich; Kamal Dua

doi:10.1016/j.matlet.2022.132600

Versatility of acetalated dextran in nanocarriers targeting respiratory diseases

Parteek Prasher
, Mousmee Sharma
, Sachin Kumar Singh
, Monica Gulati
, Deepak Kumar
, Gaurav Gupta
, Dinesh Kumar Chellappan
, Brian Gregory George Oliver
, Peter R. Wich
, Kamal Dua

University of Petroleum and Energy Studies
Uttaranchal University
Lovely Professional University
University of Technology Sydney
Shoolini University of Biotechnology and Management Sciences
Suresh Gyan Vihar University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
International Medical University
University of Sydney
University of New South Wales

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Acetalated dextran is a chemically modified version of the FDA approved polysaccharide ‘dextran’, which serves as a perspective drug-delivery material for the pulmonary delivery of therapeutics owing to its biodegradability, sensitivity towards acidic pH for stimuli-sensitive drug release, high encapsulation efficacy, chemical conjugation with pharmaceuticals, and potency to cross the mucosal layer. Mainly, the aerosolized dry powder inhalation formulations of drug-loaded acetalated-dextran prove to be the frontrunner candidates for pulmonary delivery for the effective management of chronic respiratory diseases such as lymphangioleiomyomatosis, tularemia, and the contemporary COVID-19 pandemic. The presented communication provides a succinct account of the pulmonary drug delivery applications of acetalated dextran.

Original language	English
Article number	132600
Journal	Materials Letters
Volume	323
DOIs	https://doi.org/10.1016/j.matlet.2022.132600
State	Published - 15 Sep 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acetalated dextran
COVID-19
Pulmonary delivery

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10.1016/j.matlet.2022.132600

Cite this

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title = "Versatility of acetalated dextran in nanocarriers targeting respiratory diseases",

abstract = "Acetalated dextran is a chemically modified version of the FDA approved polysaccharide {\textquoteleft}dextran{\textquoteright}, which serves as a perspective drug-delivery material for the pulmonary delivery of therapeutics owing to its biodegradability, sensitivity towards acidic pH for stimuli-sensitive drug release, high encapsulation efficacy, chemical conjugation with pharmaceuticals, and potency to cross the mucosal layer. Mainly, the aerosolized dry powder inhalation formulations of drug-loaded acetalated-dextran prove to be the frontrunner candidates for pulmonary delivery for the effective management of chronic respiratory diseases such as lymphangioleiomyomatosis, tularemia, and the contemporary COVID-19 pandemic. The presented communication provides a succinct account of the pulmonary drug delivery applications of acetalated dextran.",

keywords = "Acetalated dextran, COVID-19, Pulmonary delivery",

author = "Parteek Prasher and Mousmee Sharma and \{Kumar Singh\}, Sachin and Monica Gulati and Deepak Kumar and Gaurav Gupta and \{Kumar Chellappan\}, Dinesh and \{Gregory George Oliver\}, Brian and Wich, \{Peter R.\} and Kamal Dua",

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year = "2022",

month = sep,

day = "15",

doi = "10.1016/j.matlet.2022.132600",

language = "English",

volume = "323",

journal = "Materials Letters",

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T1 - Versatility of acetalated dextran in nanocarriers targeting respiratory diseases

AU - Prasher, Parteek

AU - Sharma, Mousmee

AU - Kumar Singh, Sachin

AU - Gulati, Monica

AU - Kumar, Deepak

AU - Gupta, Gaurav

AU - Kumar Chellappan, Dinesh

AU - Gregory George Oliver, Brian

AU - Wich, Peter R.

AU - Dua, Kamal

PY - 2022/9/15

Y1 - 2022/9/15

N2 - Acetalated dextran is a chemically modified version of the FDA approved polysaccharide ‘dextran’, which serves as a perspective drug-delivery material for the pulmonary delivery of therapeutics owing to its biodegradability, sensitivity towards acidic pH for stimuli-sensitive drug release, high encapsulation efficacy, chemical conjugation with pharmaceuticals, and potency to cross the mucosal layer. Mainly, the aerosolized dry powder inhalation formulations of drug-loaded acetalated-dextran prove to be the frontrunner candidates for pulmonary delivery for the effective management of chronic respiratory diseases such as lymphangioleiomyomatosis, tularemia, and the contemporary COVID-19 pandemic. The presented communication provides a succinct account of the pulmonary drug delivery applications of acetalated dextran.

AB - Acetalated dextran is a chemically modified version of the FDA approved polysaccharide ‘dextran’, which serves as a perspective drug-delivery material for the pulmonary delivery of therapeutics owing to its biodegradability, sensitivity towards acidic pH for stimuli-sensitive drug release, high encapsulation efficacy, chemical conjugation with pharmaceuticals, and potency to cross the mucosal layer. Mainly, the aerosolized dry powder inhalation formulations of drug-loaded acetalated-dextran prove to be the frontrunner candidates for pulmonary delivery for the effective management of chronic respiratory diseases such as lymphangioleiomyomatosis, tularemia, and the contemporary COVID-19 pandemic. The presented communication provides a succinct account of the pulmonary drug delivery applications of acetalated dextran.

KW - Acetalated dextran

KW - COVID-19

KW - Pulmonary delivery

UR - https://www.scopus.com/pages/publications/85131690281

U2 - 10.1016/j.matlet.2022.132600

DO - 10.1016/j.matlet.2022.132600

M3 - Article

AN - SCOPUS:85131690281

SN - 0167-577X

VL - 323

JO - Materials Letters

JF - Materials Letters

M1 - 132600

ER -

Versatility of acetalated dextran in nanocarriers targeting respiratory diseases

Abstract

UN SDGs

Keywords

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