UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW

Md Sadique Hussain; Obaid Afzal; Gaurav Gupta; Ahsas Goyal; Waleed Hassan Almalki; Imran Kazmi; Sami I. Alzarea; Abdulmalik Saleh Alfawaz Altamimi; Neelam Kukreti; Amlan Chakraborty; Sachin Kumar Singh; Kamal Dua

doi:10.17179/excli2023-6553

UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW

Md Sadique Hussain
, Obaid Afzal
, Gaurav Gupta
, Ahsas Goyal
, Waleed Hassan Almalki
, Imran Kazmi
, Sami I. Alzarea
, Abdulmalik Saleh Alfawaz Altamimi
, Neelam Kukreti
, Amlan Chakraborty
, Sachin Kumar Singh
, Kamal Dua

Jaipur National University
Prince Sattam Bin Abdulaziz University
Suresh Gyan Vihar University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
GLA University
Umm Al-Qura University
Faculty of Sciences, King Abdulaziz University
Al Jouf University
Graphic Era Hill University
University of Manchester
Monash University
Lovely Professional University
University of Technology Sydney

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.

Original language	English
Pages (from-to)	34-52
Number of pages	19
Journal	EXCLI Journal
Volume	23
DOIs	https://doi.org/10.17179/excli2023-6553
State	Published - 3 Jan 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Long non-coding RNA
NEAT1
cancer
clinical applications
lung cancer

Access to Document

10.17179/excli2023-6553

Cite this

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title = "UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW",

abstract = "This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.",

keywords = "Long non-coding RNA, NEAT1, cancer, clinical applications, lung cancer",

author = "Hussain, \{Md Sadique\} and Obaid Afzal and Gaurav Gupta and Ahsas Goyal and Almalki, \{Waleed Hassan\} and Imran Kazmi and Alzarea, \{Sami I.\} and Altamimi, \{Abdulmalik Saleh Alfawaz\} and Neelam Kukreti and Amlan Chakraborty and Singh, \{Sachin Kumar\} and Kamal Dua",

year = "2024",

month = jan,

day = "3",

doi = "10.17179/excli2023-6553",

language = "English",

volume = "23",

pages = "34--52",

journal = "EXCLI Journal",

issn = "1611-2156",

publisher = "Leibniz Research Centre for Working Environment and Human Factors",

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T1 - UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY

T2 - A COMPREHENSIVE REVIEW

AU - Hussain, Md Sadique

AU - Afzal, Obaid

AU - Gupta, Gaurav

AU - Goyal, Ahsas

AU - Almalki, Waleed Hassan

AU - Kazmi, Imran

AU - Alzarea, Sami I.

AU - Altamimi, Abdulmalik Saleh Alfawaz

AU - Kukreti, Neelam

AU - Chakraborty, Amlan

AU - Singh, Sachin Kumar

AU - Dua, Kamal

PY - 2024/1/3

Y1 - 2024/1/3

N2 - This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.

AB - This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.

KW - Long non-coding RNA

KW - NEAT1

KW - cancer

KW - clinical applications

KW - lung cancer

UR - https://www.scopus.com/pages/publications/85182473080

U2 - 10.17179/excli2023-6553

DO - 10.17179/excli2023-6553

M3 - Review article

AN - SCOPUS:85182473080

SN - 1611-2156

VL - 23

SP - 34

EP - 52

JO - EXCLI Journal

JF - EXCLI Journal

ER -

UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW

Abstract

UN SDGs

Keywords

Access to Document

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