Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI2 Nanoparticles as an Efficient Catalyst

M. Hussien; T. E. Ali; I. E.El Sayed; A. H. Abdelaleem; H. M. Torkey; M. A. Assiri; I. S. Yahia

doi:10.1134/S1070428023070138

Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI₂ Nanoparticles as an Efficient Catalyst

M. Hussien
, T. E. Ali
, I. E.El Sayed
, A. H. Abdelaleem
, H. M. Torkey
, M. A. Assiri
, I. S. Yahia

Agricultural Research Center, Giza
Menoufia University
King Khalid University
Ain Shams University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Abstract: Some novel 1,3-diarylpyrazolyl α-aminophosphonates conjugated with nitrogen heterocycles were synthesized via one-pot three-component reaction of 1,3-diaryl-1H-pyrazole-4-carbaldehydes, N-amino heterocycles, and diethyl phosphonate in the presence of CdI₂ nanoparticles as an efficient catalyst under conventional heating at 80°C or ultrasonic (US) irradiation at 50°C. The latter protocol has essential advantages such as operational simplicity and excellent yields. The antifungal properties of the synthesized compounds were evaluated. Most of them showed excellent inhibitory activity against plant pathogenic fungi in comparison to propiconazole as reference fungicide.

Original language	English
Pages (from-to)	1214-1223
Number of pages	10
Journal	Russian Journal of Organic Chemistry
Volume	59
Issue number	7
DOIs	https://doi.org/10.1134/S1070428023070138
State	Published - Jul 2023
Externally published	Yes

Keywords

CdI nanoparticles
Kabachnik–Fields reaction
antifungal activity
pyrazole
ultrasound
α-aminophosphonate

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10.1134/S1070428023070138

Cite this

Hussien, M., Ali, T. E., Sayed, I. E. E., Abdelaleem, A. H., Torkey, H. M., Assiri, M. A., & Yahia, I. S. (2023). Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI₂ Nanoparticles as an Efficient Catalyst. Russian Journal of Organic Chemistry, 59(7), 1214-1223. https://doi.org/10.1134/S1070428023070138

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title = "Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI2 Nanoparticles as an Efficient Catalyst",

abstract = "Abstract: Some novel 1,3-diarylpyrazolyl α-aminophosphonates conjugated with nitrogen heterocycles were synthesized via one-pot three-component reaction of 1,3-diaryl-1H-pyrazole-4-carbaldehydes, N-amino heterocycles, and diethyl phosphonate in the presence of CdI2 nanoparticles as an efficient catalyst under conventional heating at 80°C or ultrasonic (US) irradiation at 50°C. The latter protocol has essential advantages such as operational simplicity and excellent yields. The antifungal properties of the synthesized compounds were evaluated. Most of them showed excellent inhibitory activity against plant pathogenic fungi in comparison to propiconazole as reference fungicide.",

keywords = "CdI nanoparticles, Kabachnik–Fields reaction, antifungal activity, pyrazole, ultrasound, α-aminophosphonate",

author = "M. Hussien and Ali, \{T. E.\} and Sayed, \{I. E.El\} and Abdelaleem, \{A. H.\} and Torkey, \{H. M.\} and Assiri, \{M. A.\} and Yahia, \{I. S.\}",

note = "Publisher Copyright: {\textcopyright} 2023, Pleiades Publishing, Ltd.",

year = "2023",

month = jul,

doi = "10.1134/S1070428023070138",

language = "English",

volume = "59",

pages = "1214--1223",

journal = "Russian Journal of Organic Chemistry",

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publisher = "Pleiades Publishing",

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Hussien, M, Ali, TE, Sayed, IEE, Abdelaleem, AH, Torkey, HM, Assiri, MA & Yahia, IS 2023, 'Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI₂ Nanoparticles as an Efficient Catalyst', Russian Journal of Organic Chemistry, vol. 59, no. 7, pp. 1214-1223. https://doi.org/10.1134/S1070428023070138

Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI₂ Nanoparticles as an Efficient Catalyst. / Hussien, M.; Ali, T. E.; Sayed, I. E.El et al.
In: Russian Journal of Organic Chemistry, Vol. 59, No. 7, 07.2023, p. 1214-1223.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI2 Nanoparticles as an Efficient Catalyst

AU - Hussien, M.

AU - Ali, T. E.

AU - Sayed, I. E.El

AU - Abdelaleem, A. H.

AU - Torkey, H. M.

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Y1 - 2023/7

N2 - Abstract: Some novel 1,3-diarylpyrazolyl α-aminophosphonates conjugated with nitrogen heterocycles were synthesized via one-pot three-component reaction of 1,3-diaryl-1H-pyrazole-4-carbaldehydes, N-amino heterocycles, and diethyl phosphonate in the presence of CdI2 nanoparticles as an efficient catalyst under conventional heating at 80°C or ultrasonic (US) irradiation at 50°C. The latter protocol has essential advantages such as operational simplicity and excellent yields. The antifungal properties of the synthesized compounds were evaluated. Most of them showed excellent inhibitory activity against plant pathogenic fungi in comparison to propiconazole as reference fungicide.

AB - Abstract: Some novel 1,3-diarylpyrazolyl α-aminophosphonates conjugated with nitrogen heterocycles were synthesized via one-pot three-component reaction of 1,3-diaryl-1H-pyrazole-4-carbaldehydes, N-amino heterocycles, and diethyl phosphonate in the presence of CdI2 nanoparticles as an efficient catalyst under conventional heating at 80°C or ultrasonic (US) irradiation at 50°C. The latter protocol has essential advantages such as operational simplicity and excellent yields. The antifungal properties of the synthesized compounds were evaluated. Most of them showed excellent inhibitory activity against plant pathogenic fungi in comparison to propiconazole as reference fungicide.

KW - CdI nanoparticles

KW - Kabachnik–Fields reaction

KW - antifungal activity

KW - pyrazole

KW - ultrasound

KW - α-aminophosphonate

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JO - Russian Journal of Organic Chemistry

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ER -

Ultrasound-Assisted Synthesis of Some Novel 1,3-Diarylpyrazolyl α-Aminophosphonates Conjugated with Nitrogen Heterocycles as Antifungal Agents using CdI₂ Nanoparticles as an Efficient Catalyst

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Keywords

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