Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems

Rajendra Awasthi; Jyotsana R. Madan; Himaja Malipeddi; Kamal Dua; Giriraj T. Kulkarni

doi:10.21037/ncri.2019.02.02

Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems

Rajendra Awasthi
, Jyotsana R. Madan
, Himaja Malipeddi
, Kamal Dua
, Giriraj T. Kulkarni

Amity University, Noida
University of Pune
Vellore Institute of Technology
University of Technology Sydney

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Since, the first report on discovery of double helical structure of DNA by James Watson and Francis Crkk (April 1953, Nature), numerous papers have been published reporting function of non-coding RNAs (ncRNAs). On the basis of evidence and the expert’s opinion, it is well documented that majority of the human genome encodes RNAs that do not code for proteins. The aim of this communication is to summarize the importance of ncRNAs as regulators of several biological and developmental processes. Finally, this laconic review focuses on the approaches investigated for the delivery of ncRNAs.

Original language	English
Article number	11
Journal	Non-Coding RNA Investigation
Volume	3
Issue number	MARCH
DOIs	https://doi.org/10.21037/ncri.2019.02.02
State	Published - Mar 2019
Externally published	Yes

Keywords

Circular RNAs (circRNAs)
Piwi-interacting RNA (piRNA)
human genome
long non-coding RNA (lncRNA)
micro RNA (miRNA)
non-coding RNAs (ncRNAs)

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10.21037/ncri.2019.02.02

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title = "Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems",

abstract = "Since, the first report on discovery of double helical structure of DNA by James Watson and Francis Crkk (April 1953, Nature), numerous papers have been published reporting function of non-coding RNAs (ncRNAs). On the basis of evidence and the expert{\textquoteright}s opinion, it is well documented that majority of the human genome encodes RNAs that do not code for proteins. The aim of this communication is to summarize the importance of ncRNAs as regulators of several biological and developmental processes. Finally, this laconic review focuses on the approaches investigated for the delivery of ncRNAs.",

keywords = "Circular RNAs (circRNAs), Piwi-interacting RNA (piRNA), human genome, long non-coding RNA (lncRNA), micro RNA (miRNA), non-coding RNAs (ncRNAs)",

author = "Rajendra Awasthi and Madan, \{Jyotsana R.\} and Himaja Malipeddi and Kamal Dua and Kulkarni, \{Giriraj T.\}",

year = "2019",

month = mar,

doi = "10.21037/ncri.2019.02.02",

language = "English",

volume = "3",

journal = "Non-Coding RNA Investigation",

issn = "2522-6673",

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T1 - Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems

AU - Awasthi, Rajendra

AU - Madan, Jyotsana R.

AU - Malipeddi, Himaja

AU - Dua, Kamal

AU - Kulkarni, Giriraj T.

PY - 2019/3

Y1 - 2019/3

N2 - Since, the first report on discovery of double helical structure of DNA by James Watson and Francis Crkk (April 1953, Nature), numerous papers have been published reporting function of non-coding RNAs (ncRNAs). On the basis of evidence and the expert’s opinion, it is well documented that majority of the human genome encodes RNAs that do not code for proteins. The aim of this communication is to summarize the importance of ncRNAs as regulators of several biological and developmental processes. Finally, this laconic review focuses on the approaches investigated for the delivery of ncRNAs.

AB - Since, the first report on discovery of double helical structure of DNA by James Watson and Francis Crkk (April 1953, Nature), numerous papers have been published reporting function of non-coding RNAs (ncRNAs). On the basis of evidence and the expert’s opinion, it is well documented that majority of the human genome encodes RNAs that do not code for proteins. The aim of this communication is to summarize the importance of ncRNAs as regulators of several biological and developmental processes. Finally, this laconic review focuses on the approaches investigated for the delivery of ncRNAs.

KW - Circular RNAs (circRNAs)

KW - Piwi-interacting RNA (piRNA)

KW - human genome

KW - long non-coding RNA (lncRNA)

KW - micro RNA (miRNA)

KW - non-coding RNAs (ncRNAs)

UR - https://www.scopus.com/pages/publications/85089083953

U2 - 10.21037/ncri.2019.02.02

DO - 10.21037/ncri.2019.02.02

M3 - Review article

AN - SCOPUS:85089083953

SN - 2522-6673

VL - 3

JO - Non-Coding RNA Investigation

JF - Non-Coding RNA Investigation

IS - MARCH

M1 - 11

ER -

Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems

Abstract

Keywords

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