Therapeutic perspective of postbiotics in managing health of women with polycystic ovarian syndrome: a holistic approach

Polycystic Ovary Syndrome (PCOS) is an amalgamation of several factors such as complex combination of endocrine and metabolic disorder caused due to insulin resistance, hyperandrogenism and chronic inflammation. Research shows that postbiotics and their metabolic byproducts represent a new therapeutic opportunity for PCOS treatment. Postbiotics produce various therapeutic properties including anti-inflammatory, antioxidant and immunomodulatory effects that assist in balancing the metabolism. Postbiotics strengthen gut wall integrity and reduces inflammation while it affects the interaction between gut and ovaries to stabilize hormone regulation and insulin activity. Postbiotic compounds containing short-chain fatty acids (SCFAs) and microbial-derived enzymes possess the ability to enhance glucose metabolism and reduce androgen excess and support ovarian function. Malfunctioning of the gut leads to several abnormalities such as anorexia, weight gain and maintaining healthy gut homeostasis restores the same. Additionally, it restores menstrual irregularity and ovulation. Postbiotics have superior stability characteristics which provide safe operation during production and simplified formulation processes. The nature of postbiotics emerges as a promising therapy for managing PCOS since they address metabolic and reproductive disorders through microbiome-based operations.