The therapeutic potential of the labdane diterpenoid forskolin

Bahare Salehi; Mariola Staniak; Katarzyna Czopek; Anna Stepień; Kamal Dua; Ridhima Wadhwa; Dinesh Kumar Chellappan; Oksana Sytar; Marian Brestic; Namrata Ganesh Bhat; Nanjangud Venkatesh Anil Kumar; María del Mar Contreras; Farukh Sharopov; William C. Cho; Javad Sharifi-Rad

doi:10.3390/app9194089

The therapeutic potential of the labdane diterpenoid forskolin

Bahare Salehi
, Mariola Staniak
, Katarzyna Czopek
, Anna Stepień
, Kamal Dua
, Ridhima Wadhwa
, Dinesh Kumar Chellappan
, Oksana Sytar
, Marian Brestic
, Namrata Ganesh Bhat
, Nanjangud Venkatesh Anil Kumar
, María del Mar Contreras
, Farukh Sharopov
, William C. Cho
, Javad Sharifi-Rad

Bam University of Medical Sciences
Institute of Soil Science and Plant Cultivation
University of Technology Sydney
University of Newcastle
South Asian University
International Medical University
Kyiv National Taras Shevchenko University
Slovak University of Agriculture in Nitra
Manipal Academy of Higher Education
University of Jaén
Avicenna Tajik State Medical University
Queen Elizabeth Hospital Hong Kong
Jiroft University of Medical Sciences

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

Original language	English
Article number	4089
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	19
DOIs	https://doi.org/10.3390/app9194089
State	Published - 1 Oct 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CAMP pathway
Coleus forskohlii
Forskolin
Plant secondary metabolites

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10.3390/app9194089

Cite this

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title = "The therapeutic potential of the labdane diterpenoid forskolin",

abstract = "Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.",

keywords = "CAMP pathway, Coleus forskohlii, Forskolin, Plant secondary metabolites",

author = "Bahare Salehi and Mariola Staniak and Katarzyna Czopek and Anna Stepie{\'n} and Kamal Dua and Ridhima Wadhwa and Chellappan, \{Dinesh Kumar\} and Oksana Sytar and Marian Brestic and Bhat, \{Namrata Ganesh\} and Kumar, \{Nanjangud Venkatesh Anil\} and Contreras, \{Mar{\'i}a del Mar\} and Farukh Sharopov and Cho, \{William C.\} and Javad Sharifi-Rad",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

month = oct,

day = "1",

doi = "10.3390/app9194089",

language = "English",

volume = "9",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

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TY - JOUR

T1 - The therapeutic potential of the labdane diterpenoid forskolin

AU - Salehi, Bahare

AU - Staniak, Mariola

AU - Czopek, Katarzyna

AU - Stepień, Anna

AU - Dua, Kamal

AU - Wadhwa, Ridhima

AU - Chellappan, Dinesh Kumar

AU - Sytar, Oksana

AU - Brestic, Marian

AU - Bhat, Namrata Ganesh

AU - Kumar, Nanjangud Venkatesh Anil

AU - Contreras, María del Mar

AU - Sharopov, Farukh

AU - Cho, William C.

AU - Sharifi-Rad, Javad

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

AB - Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

KW - CAMP pathway

KW - Coleus forskohlii

KW - Forskolin

KW - Plant secondary metabolites

UR - https://www.scopus.com/pages/publications/85073297648

U2 - 10.3390/app9194089

DO - 10.3390/app9194089

M3 - Review article

AN - SCOPUS:85073297648

SN - 2076-3417

VL - 9

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 19

M1 - 4089

ER -

The therapeutic potential of the labdane diterpenoid forskolin

Abstract

UN SDGs

Keywords

Access to Document

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