@inbook{41253f0341c54b2dbb3bf87a06b3b0c0,
title = "The Effect of Mechanical Load-induced Intraosseous Pressure Gradients on Bone Remodeling",
abstract = "It is well established that changes in bone blood and interstitial fluid flows are associated with changes in the bone remodeling process. These flows in bone are a result not only of trans-cortical pressure gradients produced by vascular and hydro-static pressure, but also of mechanical loadings. Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects which, in turn, may enable bone cells to detect external mechanical signals. In this paper, the exploitation of a 2D continuum model based on classical poroelasticity is presented within a variational framework. The investigation is aimed at describing how mechanical actions can affect the remodeling process of a bone tissue. The focus is on the introduction of a physically motivated strain energy contribution aimed to take into account the presence of saturating fluid in the interconnected pores of bone tissue. The interaction with a bio-resorbable organic ceramic material like those used in bone graft implants is also considered in presented model. Numerical results are provided in a relevant exemplary case.",
keywords = "Bone functional adaptation, Bone remodeling, Growth resorption processes, Mechanical–biological coupling",
author = "Emilio Barchiesi and Ivan Giorgio and Faris Alzahrani and Tasawar Hayat",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",
year = "2019",
doi = "10.1007/978-3-030-13307-8\_3",
language = "English",
series = "Advanced Structured Materials",
publisher = "Springer Verlag",
pages = "29--49",
booktitle = "Advanced Structured Materials",
address = "Germany",
}