The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials

Trias Mahmudiono; Saade Abdalkareem Jasim; Yasir Salam Karim; Dmitry Olegovich Bokov; Walid Kamal Abdelbasset; Kholmurod S. Akhmedov; Ghulam Yasin; Lakshmi Thangavelu; Yasser Fakri Mustafa; Shehla Shoukat; Mazin A.A. Najm; Mohammad Amraei

doi:10.1002/ptr.7566

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials

Trias Mahmudiono
, Saade Abdalkareem Jasim
, Yasir Salam Karim
, Dmitry Olegovich Bokov
, Walid Kamal Abdelbasset
, Kholmurod S. Akhmedov
, Ghulam Yasin
, Lakshmi Thangavelu
, Yasser Fakri Mustafa
, Shehla Shoukat
, Mazin A.A. Najm
, Mohammad Amraei

Universitas Airlangga
Al-Maarif University College
Al-Manara College for Medical Sciences
Al-Nisour University College
Sechenov First Moscow State Medical University
Biotechnology and Food Safety
Prince Sattam Bin Abdulaziz University
Cairo University
Tashkent Medical Academy
Bahauddin Zakariya University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
University of Mosul
Pakistan Agricultural Research Council
Al-Ayen University
Lorestan University of Medical Sciences

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.

Original language	English
Pages (from-to)	3766-3773
Number of pages	8
Journal	Phytotherapy Research
Volume	36
Issue number	10
DOIs	https://doi.org/10.1002/ptr.7566
State	Published - Oct 2022
Externally published	Yes

Keywords

blood pressure
flaxseed
hypertension
meta-analysis
systematic review

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10.1002/ptr.7566

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Mahmudiono, T., Jasim, S. A., Karim, Y. S., Bokov, D. O., Abdelbasset, W. K., Akhmedov, K. S., Yasin, G., Thangavelu, L., Mustafa, Y. F., Shoukat, S., Najm, M. A. A., & Amraei, M. (2022). The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytotherapy Research, 36(10), 3766-3773. https://doi.org/10.1002/ptr.7566

@article{7da58d7bfaec49e7b77cb3dd72180a90,

title = "The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials",

abstract = "We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95\% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95\% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.",

keywords = "blood pressure, flaxseed, hypertension, meta-analysis, systematic review",

author = "Trias Mahmudiono and Jasim, \{Saade Abdalkareem\} and Karim, \{Yasir Salam\} and Bokov, \{Dmitry Olegovich\} and Abdelbasset, \{Walid Kamal\} and Akhmedov, \{Kholmurod S.\} and Ghulam Yasin and Lakshmi Thangavelu and Mustafa, \{Yasser Fakri\} and Shehla Shoukat and Najm, \{Mazin A.A.\} and Mohammad Amraei",

note = "Publisher Copyright: {\textcopyright} 2022 John Wiley \& Sons Ltd.",

year = "2022",

month = oct,

doi = "10.1002/ptr.7566",

language = "English",

volume = "36",

pages = "3766--3773",

journal = "Phytotherapy Research",

issn = "0951-418X",

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Mahmudiono, T, Jasim, SA, Karim, YS, Bokov, DO, Abdelbasset, WK, Akhmedov, KS, Yasin, G, Thangavelu, L, Mustafa, YF, Shoukat, S, Najm, MAA & Amraei, M 2022, 'The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials', Phytotherapy Research, vol. 36, no. 10, pp. 3766-3773. https://doi.org/10.1002/ptr.7566

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. / Mahmudiono, Trias; Jasim, Saade Abdalkareem; Karim, Yasir Salam et al.
In: Phytotherapy Research, Vol. 36, No. 10, 10.2022, p. 3766-3773.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders

T2 - A systematic review and meta-analysis of randomized clinical trials

AU - Mahmudiono, Trias

AU - Jasim, Saade Abdalkareem

AU - Karim, Yasir Salam

AU - Bokov, Dmitry Olegovich

AU - Abdelbasset, Walid Kamal

AU - Akhmedov, Kholmurod S.

AU - Yasin, Ghulam

AU - Thangavelu, Lakshmi

AU - Mustafa, Yasser Fakri

AU - Shoukat, Shehla

AU - Najm, Mazin A.A.

AU - Amraei, Mohammad

PY - 2022/10

Y1 - 2022/10

N2 - We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.

AB - We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.

KW - blood pressure

KW - flaxseed

KW - hypertension

KW - meta-analysis

KW - systematic review

UR - https://www.scopus.com/pages/publications/85135019231

U2 - 10.1002/ptr.7566

DO - 10.1002/ptr.7566

M3 - Review article

C2 - 35859037

AN - SCOPUS:85135019231

SN - 0951-418X

VL - 36

SP - 3766

EP - 3773

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 10

ER -

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials

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