Abstract
Infectious diseases are a major threat throughout the world and are caused by microorganisms, specifically bacteria. Various antibiotics are synthesized and used against infectious diseases to minimize death rate. Tetracyclines and chloramphenicol are broad-spectrum antibiotics discovered as natural products having broad-spectrum activities. This chapter discusses along with their historical importance, structure–activity relationship studies, mechanism of action, pharmacokinetics/metabolism, and synthesis of newer tetracyclines and chloramphenicol.
| Original language | English |
|---|---|
| Title of host publication | Medicinal Chemistry of Chemotherapeutic Agents |
| Subtitle of host publication | a Comprehensive Resource of Anti-infective and Anti-cancer Drugs |
| Publisher | Elsevier |
| Pages | 115-133 |
| Number of pages | 19 |
| ISBN (Electronic) | 9780323905756 |
| DOIs | |
| State | Published - 1 Jan 2023 |
Keywords
- Chloramphenicol
- DCBA naphthacene
- Epietetracycline
- Lomefloxacin
- Ribosomal binding
- Rolitetracycline
- Synthesis of tetracyclines
- Tetracyclines
- Tigecycline
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