Targeted Anticancer Agents

Molecular inhibitors that block specific cancer-causing molecules fall into a diverse class of cancer drugs called targeted agents. These compounds include agents that inhibit sustained proliferative signaling, interfere with angiogenesis, promote cell death, and stimulate the immune response against cancer. Targeted therapies are generally less toxic than traditional chemotherapy, but must also be administered for longer periods of time. Agents discussed include hormones, antihormones, kinase inhibitors, monoclonal antibodies, small molecules, and cytokines. This chapter presents the mechanisms of action of targeted agents, as well as their pharmacokinetics and toxicity profiles. New directions in cancer therapy are discussed, including the development of new drugs and the concept of personalized medicine.