Tailoring the release of drugs using excipients

Chandrasekhar Garapati; Himanshu Gupta; Jwala Renukuntla; Sai H.S. Boddu

doi:10.1007/978-3-319-20206-8_8

Tailoring the release of drugs using excipients

Chandrasekhar Garapati
, Himanshu Gupta
, Jwala Renukuntla
, Sai H.S. Boddu

University of Toledo
South College

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Current efforts in the area of drug delivery include the development of modified release technologies for improving product efficacy, safety, and patient compliance. Polymeric excipients play a critical role in determining the mechanism and rate of drug release from the solid oral dosage forms. Regardless of the physicochemical properties of drug molecules and physiological conditions of the body, it is now possible to achieve site-specific delivery of drugs in a sustained manner. This chapter highlights the polymeric excipients that are widely used in modulating the release and enhancing the oral absorption of drugs.

Original language	English
Title of host publication	Excipient Applications in Formulation Design and Drug Delivery
Publisher	Springer International Publishing
Pages	201-236
Number of pages	36
ISBN (Electronic)	9783319202068
ISBN (Print)	9783319202051
DOIs	https://doi.org/10.1007/978-3-319-20206-8_8
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Matrix systems
Oral absorption
Polymer excipients
Pulsatile release
Sustained release

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10.1007/978-3-319-20206-8_8

Cite this

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AU - Gupta, Himanshu

AU - Renukuntla, Jwala

AU - Boddu, Sai H.S.

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AB - Current efforts in the area of drug delivery include the development of modified release technologies for improving product efficacy, safety, and patient compliance. Polymeric excipients play a critical role in determining the mechanism and rate of drug release from the solid oral dosage forms. Regardless of the physicochemical properties of drug molecules and physiological conditions of the body, it is now possible to achieve site-specific delivery of drugs in a sustained manner. This chapter highlights the polymeric excipients that are widely used in modulating the release and enhancing the oral absorption of drugs.

KW - Matrix systems

KW - Oral absorption

KW - Polymer excipients

KW - Pulsatile release

KW - Sustained release

UR - https://www.scopus.com/pages/publications/84957039438

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BT - Excipient Applications in Formulation Design and Drug Delivery

PB - Springer International Publishing

ER -

Tailoring the release of drugs using excipients

Abstract

Keywords

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