@inproceedings{794ec2adcce447b1a79789213fbf3d86,
title = "System Analysis of Target-Mediated Drug Disposition (TMDD) Models",
abstract = "In this paper we have performed system analysis of target-mediated drug disposition (TDMM) models and study their stability, steady state (long term) behavior, and complexity. The original one- and two- compartment models are represented by systems of nonlinear differential equations. It has been found that these models are unstable at three different sets of their steady state values, which limits their applicability only to short time intervals. As an extension of the two-compartment TMDD model, the quasi-equilibrium model (QE-TMDD) appear to be very complex since it is represented by the system of differential-algebraic equations. Similar conclusion holds for its variant known as the quasi-steady state QSS-TMDD model. Moreover, it was shown analytically that when the initial value of the drug-receptor complex is zero, both QE-TMDD and QSS-TMDD models produce the zero values for the drug-receptor complex at all times, which appear to be a serious drawback for the applicability of these models.",
keywords = "MM-TDMM Models, QE-TDMM, QSS-TMDD, Receptor Mediated Clearance, TMDD, Target-Mediated Drug Disposition",
author = "Verica Radisavljevic-Gajic",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 The Authors.; 9th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2022 ; Conference date: 28-08-2022 Through 31-08-2022",
year = "2022",
month = sep,
day = "1",
doi = "10.1016/j.ifacol.2023.01.018",
language = "English",
series = "IFAC-PapersOnLine",
publisher = "Elsevier B.V.",
number = "23",
pages = "74--79",
editor = "Maria Klapa and Howsmon, \{Daniel P.\} and Androulakis, \{Ioannis P.\}",
booktitle = "IFAC-PapersOnLine",
address = "Netherlands",
edition = "23",
}