SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection

Yogendra Singh; Gaurav Gupta; Imran Kazmi; Fahad A. Al-Abbasi; Poonam Negi; Dinesh Kumar Chellappan; Kamal Dua

doi:10.1111/dth.13871

SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection

Yogendra Singh
, Gaurav Gupta
, Imran Kazmi
, Fahad A. Al-Abbasi
, Poonam Negi
, Dinesh Kumar Chellappan
, Kamal Dua

Mahatma Gandhi College of Pharmaceutical Sciences
Suresh Gyan Vihar University
Faculty of Sciences, King Abdulaziz University
Shoolini University of Biotechnology and Management Sciences
International Medical University
University of Technology Sydney
University of Newcastle
Centenary Institute

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

Original language	English
Article number	e13871
Journal	Dermatologic Therapy
Volume	33
Issue number	6
DOIs	https://doi.org/10.1111/dth.13871
State	Published - 1 Nov 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
SARS-CoV-2

Access to Document

10.1111/dth.13871

Cite this

@article{4b427b7ebcfd4d4c8990cbb4ece975b2,

title = "SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection",

abstract = "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.",

keywords = "COVID-19, SARS-CoV-2",

author = "Yogendra Singh and Gaurav Gupta and Imran Kazmi and Al-Abbasi, \{Fahad A.\} and Poonam Negi and Chellappan, \{Dinesh Kumar\} and Kamal Dua",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC.",

year = "2020",

month = nov,

day = "1",

doi = "10.1111/dth.13871",

language = "English",

volume = "33",

journal = "Dermatologic Therapy",

issn = "1396-0296",

publisher = "John Wiley and Sons Inc",

number = "6",

}

TY - JOUR

T1 - SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection

AU - Singh, Yogendra

AU - Gupta, Gaurav

AU - Kazmi, Imran

AU - Al-Abbasi, Fahad A.

AU - Negi, Poonam

AU - Chellappan, Dinesh Kumar

AU - Dua, Kamal

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

AB - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

KW - COVID-19

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85087558240

U2 - 10.1111/dth.13871

DO - 10.1111/dth.13871

M3 - Article

C2 - 32558055

AN - SCOPUS:85087558240

SN - 1396-0296

VL - 33

JO - Dermatologic Therapy

JF - Dermatologic Therapy

IS - 6

M1 - e13871

ER -

SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this