Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

T. E. Ali; M. A. Assiri; I. S. Yahia; H. Y. Zahran; M. H. Meselhy; M. S.A. Hussien

doi:10.1134/S1070428021010115

Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

T. E. Ali
, M. A. Assiri
, I. S. Yahia
, H. Y. Zahran
, M. H. Meselhy
, M. S.A. Hussien

King Khalid University
Ain Shams University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Abstract: The reactions of6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilicreagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, andethyl chloroacetate, were studied. These one-pot three-component reactionsregioselectively afforded four new11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ⁵]triazaphosphepin-2-ones in69–73% yields.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Russian Journal of Organic Chemistry
Volume	57
Issue number	1
DOIs	https://doi.org/10.1134/S1070428021010115
State	Published - Jan 2021
Externally published	Yes

Keywords

pyran
pyrimidine
regioselective
synthesis
triazaphosphepine

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10.1134/S1070428021010115

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@article{fb17a214b9324218895232eb6a8d9326,

title = "Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines",

abstract = "Abstract: The reactions of6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilicreagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, andethyl chloroacetate, were studied. These one-pot three-component reactionsregioselectively afforded four new11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in69–73\% yields.",

keywords = "pyran, pyrimidine, regioselective, synthesis, triazaphosphepine",

author = "Ali, \{T. E.\} and Assiri, \{M. A.\} and Yahia, \{I. S.\} and Zahran, \{H. Y.\} and Meselhy, \{M. H.\} and Hussien, \{M. S.A.\}",

note = "Publisher Copyright: {\textcopyright} 2021, Pleiades Publishing, Ltd.",

year = "2021",

month = jan,

doi = "10.1134/S1070428021010115",

language = "English",

volume = "57",

pages = "79--84",

journal = "Russian Journal of Organic Chemistry",

issn = "1070-4280",

publisher = "Pleiades Publishing",

number = "1",

}

TY - JOUR

T1 - Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

AU - Ali, T. E.

AU - Assiri, M. A.

AU - Yahia, I. S.

AU - Zahran, H. Y.

AU - Meselhy, M. H.

AU - Hussien, M. S.A.

PY - 2021/1

Y1 - 2021/1

N2 - Abstract: The reactions of6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilicreagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, andethyl chloroacetate, were studied. These one-pot three-component reactionsregioselectively afforded four new11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in69–73% yields.

AB - Abstract: The reactions of6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilicreagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, andethyl chloroacetate, were studied. These one-pot three-component reactionsregioselectively afforded four new11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in69–73% yields.

KW - pyran

KW - pyrimidine

KW - regioselective

KW - synthesis

KW - triazaphosphepine

UR - https://www.scopus.com/pages/publications/85101770225

U2 - 10.1134/S1070428021010115

DO - 10.1134/S1070428021010115

M3 - Article

AN - SCOPUS:85101770225

SN - 1070-4280

VL - 57

SP - 79

EP - 84

JO - Russian Journal of Organic Chemistry

JF - Russian Journal of Organic Chemistry

IS - 1

ER -

Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

Abstract

Keywords

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