Rational Design of Antibacterial Agents for Multidrug-Resistant Infections

Sathish Kumar Konidala; Podila Naresh; Risy Namratha Jamullamudi; Kamma Harsha Sri; Richie Rashmin Bhandare; Afzal Basha Shaik

doi:10.1002/9781394249190.ch18

Rational Design of Antibacterial Agents for Multidrug-Resistant Infections

Sathish Kumar Konidala
, Podila Naresh
, Risy Namratha Jamullamudi
, Kamma Harsha Sri
, Richie Rashmin Bhandare
, Afzal Basha Shaik

College of Pharmacy and Health Sciences

Vignan's Foundation for Science, Technology & Research
Koneru Lakshmaiah Education Foundation
Jawaharlal Nehru Technological University Hyderabad

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The development of multidrug resistance (MDR) is the most worrying problem in treating bacterial infections. The development of MDR might be due to several factors, such as gene mutation, horizontal gene transfer, efflux pumps, resistant gene application, drug modification, and target site modification. Understanding and having sound knowledge about this mechanism is of utmost significance in the design and development of novel drug candidates for effective treatment against multidrug-resistant bacterial infections. This chapter illustrates the basic concepts and mechanisms of MDR, along with strategies that can be useful in the design and development of novel potential drugs for the treatment of resistant bacterial infections.

Original language	English
Title of host publication	Computational Methods for Rational Drug Design
Publisher	wiley
Pages	403-421
Number of pages	19
ISBN (Electronic)	9781394249190
ISBN (Print)	9781394249169
DOIs	https://doi.org/10.1002/9781394249190.ch18
State	Published - 1 Jan 2025

Keywords

antibacterial agents
antibacterial resistance
bacterial infections
drug design
multidrug resistance

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10.1002/9781394249190.ch18

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abstract = "The development of multidrug resistance (MDR) is the most worrying problem in treating bacterial infections. The development of MDR might be due to several factors, such as gene mutation, horizontal gene transfer, efflux pumps, resistant gene application, drug modification, and target site modification. Understanding and having sound knowledge about this mechanism is of utmost significance in the design and development of novel drug candidates for effective treatment against multidrug-resistant bacterial infections. This chapter illustrates the basic concepts and mechanisms of MDR, along with strategies that can be useful in the design and development of novel potential drugs for the treatment of resistant bacterial infections.",

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AU - Sri, Kamma Harsha

AU - Bhandare, Richie Rashmin

AU - Shaik, Afzal Basha

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AB - The development of multidrug resistance (MDR) is the most worrying problem in treating bacterial infections. The development of MDR might be due to several factors, such as gene mutation, horizontal gene transfer, efflux pumps, resistant gene application, drug modification, and target site modification. Understanding and having sound knowledge about this mechanism is of utmost significance in the design and development of novel drug candidates for effective treatment against multidrug-resistant bacterial infections. This chapter illustrates the basic concepts and mechanisms of MDR, along with strategies that can be useful in the design and development of novel potential drugs for the treatment of resistant bacterial infections.

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KW - antibacterial resistance

KW - bacterial infections

KW - drug design

KW - multidrug resistance

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BT - Computational Methods for Rational Drug Design

PB - wiley

ER -

Rational Design of Antibacterial Agents for Multidrug-Resistant Infections

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Keywords

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