Posaconazole concentrations in human tissues after allogeneic stem cell transplantation

Ola Blennow; Erik Eliasson; Tommy Pettersson; Anton Pohanka; Attila Szakos; Ibrahim El-Serafi; Moustapha Hassan; Olle Ringdén; Jonas Mattsson

doi:10.1128/AAC.03252-14

Posaconazole concentrations in human tissues after allogeneic stem cell transplantation

Ola Blennow
, Erik Eliasson
, Tommy Pettersson
, Anton Pohanka
, Attila Szakos
, Ibrahim El-Serafi
, Moustapha Hassan
, Olle Ringdén
, Jonas Mattsson

Karolinska Institutet

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.

Original language	English
Pages (from-to)	4941-4943
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	58
Issue number	8
DOIs	https://doi.org/10.1128/AAC.03252-14
State	Published - Aug 2014
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1128/AAC.03252-14

Cite this

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abstract = "Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.",

author = "Ola Blennow and Erik Eliasson and Tommy Pettersson and Anton Pohanka and Attila Szakos and Ibrahim El-Serafi and Moustapha Hassan and Olle Ringd{\'e}n and Jonas Mattsson",

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AU - Blennow, Ola

AU - Eliasson, Erik

AU - Pettersson, Tommy

AU - Pohanka, Anton

AU - Szakos, Attila

AU - El-Serafi, Ibrahim

AU - Hassan, Moustapha

AU - Ringdén, Olle

AU - Mattsson, Jonas

PY - 2014/8

Y1 - 2014/8

N2 - Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.

AB - Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.

UR - https://www.scopus.com/pages/publications/84905379006

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M3 - Article

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AN - SCOPUS:84905379006

SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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ER -

Posaconazole concentrations in human tissues after allogeneic stem cell transplantation

Abstract

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