Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation

Nikita Kaushal; Manish Kumar; Abhishek Tiwari; Varsha Tiwari; Kamini Sharma; Ajay Sharma; Arya Lakshmi Marisetti; Madan Mohan Gupta; Imran Kazmi; Sami I. Alzarea; Waleed Hassan Almalki; Gaurav Gupta

doi:10.2217/nnm-2023-0123

Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation

Nikita Kaushal
, Manish Kumar
, Abhishek Tiwari
, Varsha Tiwari
, Kamini Sharma
, Ajay Sharma
, Arya Lakshmi Marisetti
, Madan Mohan Gupta
, Imran Kazmi
, Sami I. Alzarea
, Waleed Hassan Almalki
, Gaurav Gupta

Maharishi Markandeshwar University, Mullana
CT University
IFTM University
Delhi Pharmaceutical Sciences and Research University
Faculty of Medical Sciences
Faculty of Sciences, King Abdulaziz University
Al Jouf University
Umm Al-Qura University
Graphic Era Hill University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

Original language	English
Pages (from-to)	1383-1398
Number of pages	16
Journal	Nanomedicine
Volume	18
Issue number	20
DOIs	https://doi.org/10.2217/nnm-2023-0123
State	Published - 1 Aug 2023
Externally published	Yes

Keywords

entrapment efficiency
ophthalmicpolymeric micelles
transcorneal permeation
uveitis

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10.2217/nnm-2023-0123

Cite this

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title = "Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation",

abstract = "Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.",

keywords = "entrapment efficiency, ophthalmicpolymeric micelles, transcorneal permeation, uveitis",

author = "Nikita Kaushal and Manish Kumar and Abhishek Tiwari and Varsha Tiwari and Kamini Sharma and Ajay Sharma and Marisetti, \{Arya Lakshmi\} and Gupta, \{Madan Mohan\} and Imran Kazmi and Alzarea, \{Sami I.\} and Almalki, \{Waleed Hassan\} and Gaurav Gupta",

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doi = "10.2217/nnm-2023-0123",

language = "English",

volume = "18",

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T1 - Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation

T2 - development and evaluation

AU - Kaushal, Nikita

AU - Kumar, Manish

AU - Tiwari, Abhishek

AU - Tiwari, Varsha

AU - Sharma, Kamini

AU - Sharma, Ajay

AU - Marisetti, Arya Lakshmi

AU - Gupta, Madan Mohan

AU - Kazmi, Imran

AU - Alzarea, Sami I.

AU - Almalki, Waleed Hassan

AU - Gupta, Gaurav

PY - 2023/8/1

Y1 - 2023/8/1

N2 - Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

AB - Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

KW - entrapment efficiency

KW - ophthalmicpolymeric micelles

KW - transcorneal permeation

KW - uveitis

UR - https://www.scopus.com/pages/publications/85176924776

U2 - 10.2217/nnm-2023-0123

DO - 10.2217/nnm-2023-0123

M3 - Article

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AN - SCOPUS:85176924776

SN - 1743-5889

VL - 18

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EP - 1398

JO - Nanomedicine

JF - Nanomedicine

IS - 20

ER -

Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation

Abstract

Keywords

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