Abstract
Dissolution of a polymer in the solvent is a crucial topic of research in polymer science owing to its diverse applications in drug delivery, membrane science, recycling, and tissue engineering. The rapid dissolution of polymer is limited by polymer structure, the presence of long chains, crystallinity, molecular weight, polydispersity, and polarity. Moreover, the polymer dissolution is controlled by the disentanglement of the polymer chains through a frontier layer closest to the polymer-solvent interface. To achieve proper dissolution of the polymer, the selection of the apt solvent is highly required. The solubility parameters are very important parameters that aid in the selection of suitable and compatible solvents to achieve better dissolution of the polymer. Various techniques have been explored to study the dissolution of polymers. This chapter discusses the significance and mechanisms of polymer dissolution, and factors affecting the dissolution of polymers. The polymers’ solubility and solubility parameters with their applications, and polymer dissolution models are also described. Furthermore, a range of techniques employed to study polymer dissolution is also discussed.
| Original language | English |
|---|---|
| Title of host publication | Polymers for Pharmaceutical and Biomedical Applications |
| Subtitle of host publication | Fundamentals, Selection, and Preparation |
| Publisher | Elsevier |
| Pages | 131-151 |
| Number of pages | 21 |
| ISBN (Electronic) | 9780323954969 |
| ISBN (Print) | 9780323954976 |
| DOIs | |
| State | Published - 1 Jan 2024 |
| Externally published | Yes |
Keywords
- Dissolution mechanisms
- Dissolution models
- Dissolution study techniques
- Polymer dissolution
- Solubility parameters
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