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Phytochemicals in drug discovery: potential as lead compounds and therapeutic agents

  • Jamia Millia Islamia
  • Mandsaur University
  • Jazan University

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The natural resources around us have been used for centuries to make phytomedicines. Phytochemicals, or bioactive substances produced by plants, have attracted much attention in the pharmaceutical industry due to their potential as lead compounds and therapeutic. Phytochemicals may be used in traditional medicine as potential treatments for a range of illnesses. By combining modern and traditional medical systems and exploring the world’s understudied biodiversity, there is a great chance to find new phytochemicals and drug leads. These chemicals, including mostly flavonoids, alkaloids, terpenoids, and phenolic acids, have demonstrated interesting biological effects, such as antioxidant, antiinflammatory, anticancer, and antibacterial activity. Their natural origin and structural diversity make them ideal candidates for pharmaceutical study, frequently resulting in novel medications and treatments. We might conclude that phytochemicals show potential in drug discovery, giving useful insights and paths for developing effective and safer medicinal molecules. With continued research and technical advancements, they have the potential to provide new medications that can treat a wide range of medical requirements. Phytochemicals act as blueprints or “lead compounds” that can be modified to boost efficacy, lower toxicity, or enhance accessibility. Many medications, such as aspirin (derived from salicylic acid in willow bark) and paclitaxel (from the Pacific yew tree), are based on natural substances that were once phytochemicals.

Original languageEnglish
Title of host publicationPhytoceuticals in Food for Health and Wellness
Subtitle of host publicationHarnessing Plant Therapeutics
PublisherElsevier
Pages653-671
Number of pages19
ISBN (Electronic)9780443264948
ISBN (Print)9780443264955
DOIs
StatePublished - 1 Jan 2025
Externally publishedYes

Keywords

  • diseases
  • drug discovery
  • lead compounds
  • Phytochemicals
  • therapeutics

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