Physicochemical properties of a nanocomposite (graphene oxide-hydroxyapatite-cellulose) immobilized by Ag nanoparticles for biomedical applications

In this study, an anti-bacterial hybrid graphene oxide/hydroxyapatite /cellulose composite membrane containing silver nanoparticles (AgNPs) was prepared and characterized by FT-IR, Raman spectroscopy, XRD, and SEM. The incorporation of GO (graphene oxide) into HAp (hydroxyapatite) created a functional group that facilitated the deposition of AgNPs. GO improved the deposition of AgNPs on cellulose fibers and prevented leaching of Ag ions resulting in effective antimicrobial activity. The synthesized composite membrane demonstrated strong antibacterial activity against gram-positive (S. aureus) and gram-negative (E. coli and C. albicans) bacteria. The synthesized nanocomposite will be highly applicable as antibacterial agent against the studied bacteria.