Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

Gaurav Gupta; Ridhima Wadhwa; Parijat Pandey; Sachin Kumar Singh; Monica Gulati; Saurabh Sajita; Meenu Mehta; Avinash Kumar Singh; Harish Dureja; Trudi Collet; Kavita Pabreja; Dinesh Kumar Chellappan; Kamal Dua

doi:10.1007/978-3-030-35358-2_5

Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

Gaurav Gupta
, Ridhima Wadhwa
, Parijat Pandey
, Sachin Kumar Singh
, Monica Gulati
, Saurabh Sajita
, Meenu Mehta
, Avinash Kumar Singh
, Harish Dureja
, Trudi Collet
, Kavita Pabreja
, Dinesh Kumar Chellappan
, Kamal Dua

Jaipur National University
South Asian University
Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research
Lovely Professional University
School of Pharmaceutical Education and Research
Maharshi Dayanand University
Queensland University of Technology
University of Newcastle
International Medical University
University of Technology Sydney
Royal Prince Alfred Hospital

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

22 Scopus citations

Abstract

Insulin resistanceInsulin resistance along with type 2 diabetesDiabetes (T2D) is some of the complications of obesityObesity. Insulin resistanceInsulin resistance occurs due to the increased discharge of fatty acids, lipids, and other advancing factors, by the adipose tissueAdipose tissue, leading to a myriad of complications. Several other substances namely glycerol, enzymes, inflammatory factors, and hormones are also involved in the overall mechanism. At the point when resistance towards insulin occurs, along with abnormally functioning β-cellsΒ-cells, the overall burden of the inability to control elevated glucose levels in the blood ensues. Anomalies in β-cellΒ-cells are thus more critical in the development of T2D and its related symptoms. This information is encouraging investigation of the molecular and hereditary basis of the ailment and new ways to deal with its management and avoidance.

Original language	English
Title of host publication	Advances in Biochemistry in Health and Disease
Publisher	Springer Nature
Pages	81-97
Number of pages	17
DOIs	https://doi.org/10.1007/978-3-030-35358-2_5
State	Published - 2020
Externally published	Yes

Publication series

Name	Advances in Biochemistry in Health and Disease
Volume	19
ISSN (Print)	2512-2142
ISSN (Electronic)	2512-2150

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diabetes
Genetic
Insulin resistance
Obesity
β-cells

Access to Document

10.1007/978-3-030-35358-2_5

Cite this

Gupta, G., Wadhwa, R., Pandey, P., Singh, S. K., Gulati, M., Sajita, S., Mehta, M., Singh, A. K., Dureja, H., Collet, T., Pabreja, K., Chellappan, D. K., & Dua, K. (2020). Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance. In Advances in Biochemistry in Health and Disease (pp. 81-97). (Advances in Biochemistry in Health and Disease; Vol. 19). Springer Nature. https://doi.org/10.1007/978-3-030-35358-2_5

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title = "Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance",

abstract = "Insulin resistanceInsulin resistance along with type 2 diabetesDiabetes (T2D) is some of the complications of obesityObesity. Insulin resistanceInsulin resistance occurs due to the increased discharge of fatty acids, lipids, and other advancing factors, by the adipose tissueAdipose tissue, leading to a myriad of complications. Several other substances namely glycerol, enzymes, inflammatory factors, and hormones are also involved in the overall mechanism. At the point when resistance towards insulin occurs, along with abnormally functioning β-cellsΒ-cells, the overall burden of the inability to control elevated glucose levels in the blood ensues. Anomalies in β-cellΒ-cells are thus more critical in the development of T2D and its related symptoms. This information is encouraging investigation of the molecular and hereditary basis of the ailment and new ways to deal with its management and avoidance.",

keywords = "Diabetes, Genetic, Insulin resistance, Obesity, β-cells",

author = "Gaurav Gupta and Ridhima Wadhwa and Parijat Pandey and Singh, \{Sachin Kumar\} and Monica Gulati and Saurabh Sajita and Meenu Mehta and Singh, \{Avinash Kumar\} and Harish Dureja and Trudi Collet and Kavita Pabreja and Chellappan, \{Dinesh Kumar\} and Kamal Dua",

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doi = "10.1007/978-3-030-35358-2\_5",

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Gupta, G, Wadhwa, R, Pandey, P, Singh, SK, Gulati, M, Sajita, S, Mehta, M, Singh, AK, Dureja, H, Collet, T, Pabreja, K, Chellappan, DK & Dua, K 2020, Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance. in Advances in Biochemistry in Health and Disease. Advances in Biochemistry in Health and Disease, vol. 19, Springer Nature, pp. 81-97. https://doi.org/10.1007/978-3-030-35358-2_5

Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance. / Gupta, Gaurav; Wadhwa, Ridhima; Pandey, Parijat et al.
Advances in Biochemistry in Health and Disease. Springer Nature, 2020. p. 81-97 (Advances in Biochemistry in Health and Disease; Vol. 19).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Obesity and Diabetes

T2 - Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

AU - Gupta, Gaurav

AU - Wadhwa, Ridhima

AU - Pandey, Parijat

AU - Singh, Sachin Kumar

AU - Gulati, Monica

AU - Sajita, Saurabh

AU - Mehta, Meenu

AU - Singh, Avinash Kumar

AU - Dureja, Harish

AU - Collet, Trudi

AU - Pabreja, Kavita

AU - Chellappan, Dinesh Kumar

AU - Dua, Kamal

PY - 2020

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AB - Insulin resistanceInsulin resistance along with type 2 diabetesDiabetes (T2D) is some of the complications of obesityObesity. Insulin resistanceInsulin resistance occurs due to the increased discharge of fatty acids, lipids, and other advancing factors, by the adipose tissueAdipose tissue, leading to a myriad of complications. Several other substances namely glycerol, enzymes, inflammatory factors, and hormones are also involved in the overall mechanism. At the point when resistance towards insulin occurs, along with abnormally functioning β-cellsΒ-cells, the overall burden of the inability to control elevated glucose levels in the blood ensues. Anomalies in β-cellΒ-cells are thus more critical in the development of T2D and its related symptoms. This information is encouraging investigation of the molecular and hereditary basis of the ailment and new ways to deal with its management and avoidance.

KW - Diabetes

KW - Genetic

KW - Insulin resistance

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KW - β-cells

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T3 - Advances in Biochemistry in Health and Disease

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BT - Advances in Biochemistry in Health and Disease

PB - Springer Nature

ER -

Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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