Novel antiglaucoma prodrugs and codrugs of ethacrynic acid

Grazyna Cynkowska; Tadeusz Cynkowski; Abeer A. Al-Ghananeem; Hong Guo; Paul Ashton; Peter A. Crooks

doi:10.1016/j.bmcl.2005.05.128

Novel antiglaucoma prodrugs and codrugs of ethacrynic acid

Grazyna Cynkowska
, Tadeusz Cynkowski
, Abeer A. Al-Ghananeem
, Hong Guo
, Paul Ashton
, Peter A. Crooks

New England Eye Center
University of Kentucky

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.

Original language	English
Pages (from-to)	3524-3527
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.128
State	Published - 1 Aug 2005
Externally published	Yes

Keywords

Atenolol
Codrug
Ethacrynic acid
Glaucoma
Prodrug
Timolol

Access to Document

10.1016/j.bmcl.2005.05.128

Cite this

@article{88a1f6b3edf8442e8c881259cd912d97,

title = "Novel antiglaucoma prodrugs and codrugs of ethacrynic acid",

abstract = "The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.",

keywords = "Atenolol, Codrug, Ethacrynic acid, Glaucoma, Prodrug, Timolol",

author = "Grazyna Cynkowska and Tadeusz Cynkowski and Al-Ghananeem, \{Abeer A.\} and Hong Guo and Paul Ashton and Crooks, \{Peter A.\}",

year = "2005",

month = aug,

day = "1",

doi = "10.1016/j.bmcl.2005.05.128",

language = "English",

volume = "15",

pages = "3524--3527",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "15",

}

TY - JOUR

T1 - Novel antiglaucoma prodrugs and codrugs of ethacrynic acid

AU - Cynkowska, Grazyna

AU - Cynkowski, Tadeusz

AU - Al-Ghananeem, Abeer A.

AU - Guo, Hong

AU - Ashton, Paul

AU - Crooks, Peter A.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.

AB - The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.

KW - Atenolol

KW - Codrug

KW - Ethacrynic acid

KW - Glaucoma

KW - Prodrug

KW - Timolol

UR - https://www.scopus.com/pages/publications/21744434731

U2 - 10.1016/j.bmcl.2005.05.128

DO - 10.1016/j.bmcl.2005.05.128

M3 - Article

C2 - 15990301

AN - SCOPUS:21744434731

SN - 0960-894X

VL - 15

SP - 3524

EP - 3527

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Novel antiglaucoma prodrugs and codrugs of ethacrynic acid

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this