Neutralizing Antibodies to COVID-19 Virus: Merits and Limitations

Severe acute respiratory syndrome coronavirus 2 (SARS COV 2), a newly emerged coronavirus swept over globally causing coronavirus disease 2019 (COVID-19) pandemic. Immunological response to SARS COV 2 is a major focus of discussion at present, from the perspectives of clinical presentation in patients, and prophylactic and therapeutic measures against the disease. A good understanding of the immunopathogenesis of the condition, and host response to the pathogen is pertinent for guiding effective treatment. In the current review, we discuss the essential concepts of neutralizing antibodies against SARS COV 2, elaborating on their mechanism of action, and their association, if any, in limiting the progression of the disease vis-à-vis in causing disease severity.