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Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy

  • Rupesh K. Gautam
  • , Pooja Mittal
  • , Rajat Goyal
  • , Kamal Dua
  • , Dinesh Kumar Mishra
  • , Sanjay Sharma
  • , Rajeev Kumar Singla
  • Sichuan University
  • Indore Institute of Pharmacy
  • Chitkara University
  • Maharishi Markandeshwar University, Mullana
  • University of Technology Sydney
  • Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management
  • Lovely Professional University

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Nanomedicine's application of nanotechnology in medicine holds tremendous potential for diagnosing and treating life-threatening diseases such as cancer. Unlike conventional therapies, nanomedicine offers a promising strategy to enhance clinical outcomes while minimizing severe side effects. The principle of drug targeting enables specific delivery of therapeutic agents to their intended sites, making it a more precise and effective therapy. Combination strategies, such as the co-delivery of chemotherapeutic drugs with nucleic acids or receptor-specific molecules, are being employed to enhance therapeutic outcomes. Nanocarriers and drug delivery systems de-signed using these approaches offer resourceful co-delivery of therapeutic agents for anticancer therapy. Targeted drug delivery via nanotechnology-based techniques has become an urgent need and has shown significant improvements in therapeutic implications, pharmacokinetics, specificity, reduced toxicity, and biocompatibility. This review discusses the extrapolation of nanomaterials for developing innovative and novel drug delivery systems for effective anticancer therapy. Additionally, we explore the role of nanotechnology-based concepts in drug delivery research.

Original languageEnglish
Pages (from-to)4479-4494
Number of pages16
JournalCurrent Medicinal Chemistry
Volume31
Issue number28
DOIs
StatePublished - 2024
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Nanomedicine
  • apoptosis
  • cancer
  • cell proliferation
  • drug delivery
  • nanoparticles
  • nanotechnology

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