Mineralized Collagen Fiber-based Dental Implant: Novel Perspectives

Aim: One of the problems that dental bone defects commonly face is less biocompatibility. Therefore, it is important to find effective natural dental materials to increase the rate of cell viability. In the present work, a blend of mineralized collagen fiber (MCF)/silica nanoparticles (Si-NPs) is used to develop a dental implant (DI), for their possible application in dental bone repair. Materials and Methods: This research study was to develop a technique for the fabrication of DI using natural materials. Accordingly, the present work provides DI, essentially by PVA (6g): MCF (1.5g): Si-NPs (0.8g): CaCO₃ (1.0g) slurry into DI with other conventional implants. The DI was characterized by its mechanical, physicochemical, and biocompatibility study. The mechanical analysis was statistically different in all three time periods (p <.05). Surface characterization of DI was carried out before and after immersion in the SBF. Results: The DI was excellent mechanical properties like compressive strength (24.22 ± 0.32 MPa) and elongation at break (16.51% ± 0.71%). The morphology of the DI showed a good pore size observed. Bioactivity test was observed on the Calcium/Phosphate of the DI. The biocompatibility of the study MTT (3-(4,5-dimethyl) thiazol-2-yl-2,5-dimethyl tetrazolium bromide) assay using the MG63 (human osteoblast cell line) has proven to more viable cell on the DI. Conclusion: The study has devised a process for using fish waste in the preparation of DI. The DI with the required strength, biocompatibility, and bone mineralization properties may be tried as a DI in large animals after obtaining the necessary approval.