Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities

Kaustubh Ajit Kolekar; Popat S. Kumbhar; John Disouza; Sukriti Vishwas; Gaurav Gupta; Kamal Dua; Vetriselvan Subramaniyan; Bey Hing Goh; Harish Dureja; Sachin Kumar Singh

doi:10.1016/B978-0-443-40366-8.00008-6

Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities

Kaustubh Ajit Kolekar
, Popat S. Kumbhar
, John Disouza
, Sukriti Vishwas
, Gaurav Gupta
, Kamal Dua
, Vetriselvan Subramaniyan
, Bey Hing Goh
, Harish Dureja
, Sachin Kumar Singh

Center of Medical and Bio-allied Health Sciences Research (CMBHSR)

Lovely Professional University
Shivaji University
SYBES’s Bombay Institute of Pharmacy and Research
Chitkara University
University of Technology Sydney
Sunway University
Maharshi Dayanand University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The parenteral route of administration is the second most popular method for medication delivery. This method is frequently employed for medications with a limited therapeutic window and low absorption or for emergency unconscious patients. Parenteral medication delivery strategies that use nanoformulation take advantage of nanotechnology to improve the safety and effectiveness of medicinal medicines. Enhancing the solubility, stability, and bioavailability of medications is the primary goal of these strategies. A promising method for parenteral drug administration is the use of micellar nanoformulations, especially for hydrophobic drugs in cancer treatment. These systems can efficiently encapsulate and transport drugs in a regulated manner because they self-assemble from amphiphilic block copolymers into nanoscale carriers. This chapter discusses the design, development, and scale-up feasibility of micelles nanoformulation for parenteral drug delivery.

Original language	English
Title of host publication	How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms
Subtitle of host publication	From Bench to the Clinics
Publisher	Elsevier
Pages	127-146
Number of pages	20
ISBN (Electronic)	9780443403668
ISBN (Print)	9780443403675
DOIs	https://doi.org/10.1016/B978-0-443-40366-8.00008-6
State	Published - 1 Jan 2026

Keywords

Scale-up feasibility
amphiphilic block copolymers
micelles
nanoformulation
parenteral delivery

Access to Document

10.1016/B978-0-443-40366-8.00008-6

Cite this

Kolekar, K. A., Kumbhar, P. S., Disouza, J., Vishwas, S., Gupta, G., Dua, K., Subramaniyan, V., Goh, B. H., Dureja, H., & Singh, S. K. (2026). Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities. In How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics (pp. 127-146). Elsevier. https://doi.org/10.1016/B978-0-443-40366-8.00008-6

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abstract = "The parenteral route of administration is the second most popular method for medication delivery. This method is frequently employed for medications with a limited therapeutic window and low absorption or for emergency unconscious patients. Parenteral medication delivery strategies that use nanoformulation take advantage of nanotechnology to improve the safety and effectiveness of medicinal medicines. Enhancing the solubility, stability, and bioavailability of medications is the primary goal of these strategies. A promising method for parenteral drug administration is the use of micellar nanoformulations, especially for hydrophobic drugs in cancer treatment. These systems can efficiently encapsulate and transport drugs in a regulated manner because they self-assemble from amphiphilic block copolymers into nanoscale carriers. This chapter discusses the design, development, and scale-up feasibility of micelles nanoformulation for parenteral drug delivery.",

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Kolekar, KA, Kumbhar, PS, Disouza, J, Vishwas, S, Gupta, G , Dua, K, Subramaniyan, V, Goh, BH, Dureja, H & Singh, SK 2026, Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities. in How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics. Elsevier, pp. 127-146. https://doi.org/10.1016/B978-0-443-40366-8.00008-6

Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities. / Kolekar, Kaustubh Ajit; Kumbhar, Popat S.; Disouza, John et al.
How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics. Elsevier, 2026. p. 127-146.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Kolekar, Kaustubh Ajit

AU - Kumbhar, Popat S.

AU - Disouza, John

AU - Vishwas, Sukriti

AU - Gupta, Gaurav

AU - Dua, Kamal

AU - Subramaniyan, Vetriselvan

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AU - Singh, Sachin Kumar

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AB - The parenteral route of administration is the second most popular method for medication delivery. This method is frequently employed for medications with a limited therapeutic window and low absorption or for emergency unconscious patients. Parenteral medication delivery strategies that use nanoformulation take advantage of nanotechnology to improve the safety and effectiveness of medicinal medicines. Enhancing the solubility, stability, and bioavailability of medications is the primary goal of these strategies. A promising method for parenteral drug administration is the use of micellar nanoformulations, especially for hydrophobic drugs in cancer treatment. These systems can efficiently encapsulate and transport drugs in a regulated manner because they self-assemble from amphiphilic block copolymers into nanoscale carriers. This chapter discusses the design, development, and scale-up feasibility of micelles nanoformulation for parenteral drug delivery.

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BT - How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms

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ER -

Micellar nanoformulations for parenteral delivery: design, development, and scale-up feasibilities

Abstract

Keywords

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