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Managing Apoptosis in Lung Diseases Using Nano-Assisted Drug Delivery System

  • Monu K. Shukla
  • , Amit Dubey
  • , Sadanand Pandey
  • , Sachin K. Singh
  • , Gaurav Gupta
  • , Parteek Prasher
  • , Dinesh K. Chellappan
  • , Brian G. Oliver
  • , Deepak Kumar
  • , Kamal Dua
  • Shoolini University of Biotechnology and Management Sciences
  • Quanta Calculus Pvt. Ltd
  • Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
  • Yeungnam University
  • Lovely Professional University
  • University of Technology Sydney
  • Suresh Gyan Vihar University
  • Uttaranchal University
  • University of Petroleum and Energy Studies
  • International Medical University
  • University of Sydney

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Several factors exist that limit the efficacy of lung cancer treatment. These may be tumor-specific delivery of therapeutics, airway geometry, humidity, clearance mechanisms, presence of lung diseases, and therapy against tumor cell resistance. Advancements in drug delivery using nanotechnology based multifunc-tional nanocarriers, have emerged as a viable method for treating lung cancer with more efficacy and fewer adverse effects. This review does a thorough and critical examination of effective nano-enabled approaches for lung cancer treatment, such as nano-assisted drug delivery systems. In addition, to therapeutic effectiveness, researchers have been working to determine several strategies to produce nanotherapeutics by adjusting the size, drug loading, transport, and retention. Personalized lung tumor therapies using sophisticated nano modali-ties have the potential to provide great therapeutic advantages based on individual unique genetic markers and disease profiles. Overall, this review provides comprehensive information on newer nanotechnological prospects for improving the management of apoptosis in lung cancer.

Original languageEnglish
Pages (from-to)3202-3211
Number of pages10
JournalCurrent Pharmaceutical Design
Volume28
Issue number39
DOIs
StatePublished - Nov 2022
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Lung cancer
  • apoptosis
  • lung diseases
  • nano-drug delivery systems
  • nanoparticles
  • nanotechnology

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