It's all about plant derived natural phytoconstituents and phytonanomedicine to control skin cancer

Nanotechnology is an emerging science for controlling cutaneous cancer and related consequences like skin melanoma. Phyto nanomedicine facilitated drug targeting, penetration, and retention with mitigated side effects as a result of topical application. Data and information were collected from various kinds of literature. Data were critically evaluated and analyzed. Due to the immense structural diversity found in them, natural resources continue to be a valuable source of new and innovative chemical entities with potential therapeutic value. Skin cancer (SC) is a deadly disease and a global challenge for healthcare professionals. Considering the frequent emergence of drug resistance, new drug discovery and clinical success are expensive and long-term processes. Therefore, phytochemicals emerged as a new window for therapeutic alternatives with convincing outcomes. These phytoconstituents and phytonanomedicines demonstrated to control SC through diverse mechanistic signaling pathways either by up-regulation or down-regulation. These have been explored in several in vitro and in vivo models. In this review, we addressed causes, pathology, and treatment options using phytonanomedicine or phytoconstituents to control SC followed by mechanistic perspectives. Perspectives on the most important phytochemicals and nanomedicines and their therapeutic potential are included in the current review.