Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis

Sajad Ahmad Dar; Shafiul Haque; Raju Kumar Mandal; Taru Singh; Mohd Wahid; Arshad Jawed; Aditya K. Panda; Naseem Akhter; Mohtashim Lohani; Mohammed Yahya Areeshi; Gargi Rai; Shyama Datt; Sambit Nath Bhattacharya; Vishnampettai Ganapathysubramanian Ramachandran; Shukla Das

doi:10.1080/08916934.2016.1261833

Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis

Sajad Ahmad Dar
, Shafiul Haque
, Raju Kumar Mandal
, Taru Singh
, Mohd Wahid
, Arshad Jawed
, Aditya K. Panda
, Naseem Akhter
, Mohtashim Lohani
, Mohammed Yahya Areeshi
, Gargi Rai
, Shyama Datt
, Sambit Nath Bhattacharya
, Vishnampettai Ganapathysubramanian Ramachandran
, Shukla Das

University of Delhi
Jazan University
Central University of Jharkhand
Al Baha University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.

Original language	English
Pages (from-to)	158-169
Number of pages	12
Journal	Autoimmunity
Volume	50
Issue number	3
DOIs	https://doi.org/10.1080/08916934.2016.1261833
State	Published - 3 Apr 2017
Externally published	Yes

Keywords

Interleukin-6
meta-analysis
rheumatoid arthritis
single nucleotide polymorphism
susceptibility

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10.1080/08916934.2016.1261833

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Dar, S. A., Haque, S., Mandal, R. K., Singh, T., Wahid, M., Jawed, A., Panda, A. K., Akhter, N., Lohani, M., Areeshi, M. Y., Rai, G., Datt, S., Bhattacharya, S. N., Ramachandran, V. G., & Das, S. (2017). Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis. Autoimmunity, 50(3), 158-169. https://doi.org/10.1080/08916934.2016.1261833

@article{1636ec39800a42e0a78772723f3f5782,

title = "Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis",

abstract = "The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95\% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95\% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95\% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95\% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95\% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95\% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95\% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95\% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95\% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95\% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95\% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.",

keywords = "Interleukin-6, meta-analysis, rheumatoid arthritis, single nucleotide polymorphism, susceptibility",

author = "Dar, \{Sajad Ahmad\} and Shafiul Haque and Mandal, \{Raju Kumar\} and Taru Singh and Mohd Wahid and Arshad Jawed and Panda, \{Aditya K.\} and Naseem Akhter and Mohtashim Lohani and Areeshi, \{Mohammed Yahya\} and Gargi Rai and Shyama Datt and Bhattacharya, \{Sambit Nath\} and Ramachandran, \{Vishnampettai Ganapathysubramanian\} and Shukla Das",

note = "Publisher Copyright: {\textcopyright} 2016 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2017",

month = apr,

day = "3",

doi = "10.1080/08916934.2016.1261833",

language = "English",

volume = "50",

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journal = "Autoimmunity",

issn = "0891-6934",

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Dar, SA, Haque, S, Mandal, RK, Singh, T, Wahid, M, Jawed, A, Panda, AK, Akhter, N, Lohani, M, Areeshi, MY, Rai, G, Datt, S, Bhattacharya, SN, Ramachandran, VG & Das, S 2017, 'Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis', Autoimmunity, vol. 50, no. 3, pp. 158-169. https://doi.org/10.1080/08916934.2016.1261833

TY - JOUR

T1 - Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis

T2 - A case-control study and meta-analysis

AU - Dar, Sajad Ahmad

AU - Haque, Shafiul

AU - Mandal, Raju Kumar

AU - Singh, Taru

AU - Wahid, Mohd

AU - Jawed, Arshad

AU - Panda, Aditya K.

AU - Akhter, Naseem

AU - Lohani, Mohtashim

AU - Areeshi, Mohammed Yahya

AU - Rai, Gargi

AU - Datt, Shyama

AU - Bhattacharya, Sambit Nath

AU - Ramachandran, Vishnampettai Ganapathysubramanian

AU - Das, Shukla

PY - 2017/4/3

Y1 - 2017/4/3

N2 - The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.

AB - The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.

KW - Interleukin-6

KW - meta-analysis

KW - rheumatoid arthritis

KW - single nucleotide polymorphism

KW - susceptibility

UR - https://www.scopus.com/pages/publications/85007197667

U2 - 10.1080/08916934.2016.1261833

DO - 10.1080/08916934.2016.1261833

M3 - Article

C2 - 28010120

AN - SCOPUS:85007197667

SN - 0891-6934

VL - 50

SP - 158

EP - 169

JO - Autoimmunity

JF - Autoimmunity

IS - 3

ER -

Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis

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Keywords

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